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Let me show you a concrete example of what makes our system unique. When asked What are the dimensions of the CYP3A4 binding pocket?, our system provides precise, quantitative answers that text-only systems simply cannot generate. The binding pocket dimensions are 12.3 angstroms by 9.6 angstroms by 7.8 angstroms along the principal axes. We identify key residues within 5 angstroms of the heme, including Phe57, Arg105, Arg106, Phe108, Ser119, and many others - a total of 17 critical residues. The pocket volume is approximately 920 cubic angstroms, which can accommodate large substrates through flexible loops at positions 210 to 220. The impact for drug design is substantial - these precise measurements guide medicinal chemistry decisions, specific residue identification enables targeted drug design, and volume calculations optimize substrate size compatibility. Importantly, text-only systems cannot provide this level of structural precision, which is essential for rational drug design. |
IEEE/ICACT20260263 Slide.13
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