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IEEE/ICACT20260263 Slide.18
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Genetic variants significantly affect drug metabolism between individuals. Our system analyzes how variants alter enzyme structure. For example, CYP2D6 star-10 reduces activity by 60% in Asian populations, while CYP2C19 star-2 creates a non-functional enzyme affecting 15-30% of patients. By inputting a patients genetic profile, we predict their metabolism capacity and enable personalized dosage adjustments for precision medicine. | |
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